J. Vet. Proin is used for dogs with urinary incontinence due to urethral sphincter hypotonus, which is poor muscle tone in the urethral sphincter. However, after the FDA approval, the same active ingredient is also used in tablets for oral use made for dogs like Proin ER (phenylpropanolamine hydrochloride extended-release), which are made by Pegasus Laboratories. Before treatment can be contemplated, an understanding of the pathophysiology of urethral sphincter mechanism incompetence is required. WebIncurin Tablets vs. Proin ER Comparison | PetMeds. J. small Anim. By CBMB on Nov 3, 2022 Incurin worked This worked within three days. Expand section Collapse section Colposuspension is intended to move the intrapelvic bladder neck of bitches with urethral sphincter mechanism incompetence to an intra-abdominal position so that increases in intra-abdominal pressure can act simultaneously on the bladder and urethra. Approximately half of affected bitches become continent following their first oestrus and should thus not be spayed earlier! The urethral sphincter is a muscular structure and is responsible for controlling the urine outflow from the bladder into the urethra. A similar variation in response is also seen with the use of alpha-adrenergic drugs Oestrogens sensitise the urethral smooth muscle to alpha-adrenergic stimulation and so a combination of oestrogen and alpha-adrenergic therapy may be useful and reduce the dose of each individual drug, lessening the chances of side effects. During the procedure, the vagina is stretched cranially and anchored on either side of the urethra to the prepubic tendon. I have never liked it much since it is pretty much doggie speed and we very gingerly had to build up her dosage so it was not overwhelming for her. Ahlstrm K, Sandahl B, Sjberg B, et al. The information is NOT to be used for diagnosis or treatment of your pet. Related Topics . Mandigers RJ, Nell T. Treatment of bitches with acquired urinary incontinence with oestriol. The agonistic and antagonistic actions of estriol. Formulations that are no longer commercially available include Uriflex-PT, Uricon, Cystolamine, and Proin Drops. J Anim Sci. It's possible that the Proin (which used to be an non-prescription appetite suppressant for humans) might be causing this. Flea Pills for Dogs: The Ultimate Guide Every Pet Owner Must Read, Cephalexin For Dogs: Recommended Dosage, Side Effects, and More, Enalapril for Dogs: Side Effects, Dosage, and More, Colloidal Silver For Dogs: A Natural Antibiotic for Sick Dogs. One study showed that sympathomimetic drugs (pseudoephedrine) were more effective at controlling urinary incontinence than DES (82.4% versus 64.5%).16 However, more recent studies of estriol have shown reported efficacies between 83% and 89.8%, similar to that of phenylpropanolamine.17,18. 61, 1353-1357. Worked great. Went from half a 75mg tab a day to two full tabs and then daily/nightly problems. The most common side effects associated with Incurin treatment under field conditions included loss of appetite, vomiting, excessive water drinking, and swollen vulva. My only reservation is that the Incurin is new and they do not know the long term effects just yet. 1987;8(5):497-505. Incurin for Dogs. 3. The Honest Kitchen Dog Food Reviewed: Pros, Cons, and Ingredient Analysis, CBD for Dog Anxiety: Top 11 Products According to a Veterinarian, The Best Probiotics For Dogs in 2022 According to a Veterinarian, The Best Cat Food for Indoor Cats: Our Top 7 Picks, CBD for Cat Anxiety: Our Top 5 Picks + Reviews, The Farmers Dog Food Reviewed: Pros, Cons, and Ingredient Analysis, Ollie Dog Food Reviewed: Pros, Cons, and Ingredient Analysis, Open Farm Cat Food Reviewed: Pros, Cons, and Ingredient Analysis, By Katelyn Son | Updated November 28, 2022. We have to get something better!! Scott L, Leddy M, Bernay F, Davot JL. Press J to jump to the feed. FREE Standard ShippingWhen You Spend $49+, EXTRA 40% OFFUse code NEW40 in cart (up to $40 discount), 2% Back on all PurchasesWith PetMeds Shop & Earn Rewards. Reddit and its partners use cookies and similar technologies to provide you with a better experience. 127, 537-542. 15% discount available for new customers only. FREE Standard ShippingWhen You Spend $49+, EXTRA 40% OFFUse code NEW40 in cart (up to $40 discount), 2% Back on all PurchasesWith PetMeds Shop & Earn Rewards. University of Bristol, Department of Clinical Veterinary ScienceLangford, Bristol, UK. Effect of phenylpropanolamine and pseudoephedrine on the urethral pressure profile and continence scores of incontinent female dogs. Nol S, Cambier C, Baert K, et al. She looked at me, whined and then I felt wet. U.S. Food and Drug Administration. Greytalk.com So my girl has been incontinent since the day I brought her home. Whilst not a cause of the condition, obesity may worsen the degree of incontinence and weight loss may improve the situation. WebMerck Animal Health announces the availability of Incurin, a new FDA-approved treatment for canine urinary incontinence in spayed females, which features convenient once-a-day dosing and a proven efficacy and safety profile. Incurin, available in 1 mg tablets, can be Performance & security by Cloudflare. J. Vet. They had me double he dosages of proin but it did not solve her leaking problem. Myocardial hypertrophy associated with long-term phenylpropanolamine use in a dog. Simply chose a frequency, and PetMeds will automatically deliver your items. The recommended dosage of Phenylpropanolamine for dogs is between 0.4 and 0.8 mg per pound of body weight (0.8 to 1.7 mg/kg) every 12 hours (twice daily). Drug interactions are possible if using Proin in conjunction with the following medications: Always store Proin in accordance with the manufacturers instructions at room temperature and away from heat, light, and moisture. Someone in my fb group sent me this article which i found pretty helpful: http://www.leospetcare.com/incurin-estriol-is-not-the-same-as-ovaban-des/ (besides the fact that it says DES is no longer available). I have had my 2.5 year old lab on Proin for a few weeks and it is helping, but her initial reaction to the meds made me a bit nervous, especially after looking up all the The treatment of cases of sphincter mechanism incompetence may be difficult and most therapies correct only one of the above factors. Nendick PA, Clark WT. 3 x 3. Urinary Incontinence in the Male and Female Dog or Does Sex Matter? Kinn AC, Lindskog M. Estrogens and phenylpropanolamine in combination for stress urinary incontinence in postmenopausal women. This is very gross, and I never get answers when I ask What turned into an appointment for eye drops, turned Our super old dog is really skinny but otherwise fine. Leakage of urine is more copious compared to animals with ureteral ectopia and occurs predominantly when the dogs are recumbent. The pathophysiology of male urethral sphincter mechanism incompetence is poorly understood, making rational treatment difficult. Two weeks and no adverse side effects. Dogs can stay on Proin for over 180 days without developing serious issues. Rainey was on DES for 5 years with 0 side effects. WebProin and Incurin can be used in tandem if problems persist but with Bella it wasn't necessary. 2002;43(11):493-496. An alternative to phenylpropanolamine medications like Proin, this safe once-daily tablet reduces and often eliminates the leakage and accidents resulting from urinary incontinence. Freedom of Information Summary. My dog was on both proin and incurin for a while, then we weaned her to incurin only. prnpharmacal.com/products/urinary-health/proin-er. 1987;64(4):117-118. New comments cannot be posted and votes cannot be cast . Madison, NJ: Intervet Inc.; 2011. INCURIN and PROIN are also the only marketed estriol and phenylpropanolamine products that are manufactured to meet FDAs strict standards for quality, purity, and potency. Incurin (estriol) Tablets for Dogs [package insert]. Incurin is contraindicated in dogs showing polyuria secondary to polydipsia, or in pregnant dogs. Has anyone had a vet prescribe both for incontinence? & Barr, F.J. (1998) Ultrasonographic assessment of bladder neck mobility in continent bitches and bitches with urinary incontinence attributable to urethral sphincter mechanism incompetence. What is your experience using either? I guess I meant when . with Rainey, she started urinating (and defecating) whenever we'd leave -- even if it was just for 40 minutes. The proportion of dogs achieving treatment success was statistically significantly greater (p = 0.0038) in the group treated with INCURIN Tablets (66%) than Since, the safe use of Proin in breeding dogs, pregnant and lactating females is not evaluated, it is best not to use the medication in these situations and avoid potential side effects. 14. Clark JH, Hardin JW, McCormack SA. He said it is a more natural medication that is basically estrogen, and that once she is stabilized on it we can drop down her dose a bit and give it less frequently (every other day). My dog takes Incurin 1mg tablets. An increased risk of hypertension has been documented in patients receiving concurrent nonsteroidal anti-inflammatory drugs (NSAIDs), reserpine, or tricyclic antidepressants. The veterinarian will prescribe the strength that best fits your dogs size and needs. Visit PetMeds to save on Incontinence. I do like that the DES can be given less frequently than the Incurin but it seems that both are low dose which is good. Accessed October 2020. After the initial load we only had to give her one pill a week, which is hardly anything. July 25, 2011. animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/882. The exact abnormality leading to urethral sphincter mechanism incompetence and the region of the urethra in which it occurs are unknown. Incurin is contraindicated in dogs showing polyuria secondary to polydipsia, or in pregnant dogs. Nendick PA, Clark WT. Hussain MA, Aungst BJ, Lam G, Shefter E. Phenylpropanolamine pharmacokinetics in dogs after intravenous, oral, and oral controlled-release doses. However due to the ease of dosing, high efficacy and safety of PROIN ER, it would be appropriate to prescribe PROIN ER first line for at least 30 days to evaluate whether another option should be explored. It also inhibits (partially blocks) a specific type of enzyme called Cytochrome P450 (CYP).
Beisland HO, Fossberg E, Moer A, Sander S. Urethral sphincteric insufficiency in postmenopausal females: treatment with phenylpropanolamine and estriol separately and in combination. Can I give her Proin along with the incurin in the mean time? Neither the Company nor any of its employees or consultants make any warranties, expressed or implied, or representations about the accuracy or completeness of the content or the content of any site or external sites. August 4, 2011. animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/881. That will teach you to keep your mouth shut." Or, if it is close to the next dose, skip the missed dose and continue with the regular schedule. -- Ernest Hemmingway, http://www.leospetcare.com/incurin-estriol-is-not-the-same-as-ovaban-des/. WebThere have never been head-to-head trials with Diethylstilbestrol (DES) or Incurin. There is considerable variation in urethral length between bitches of different sizes. Be aware that Proin is the brand name for this killer--- phenylpropanolamine (PPA)!! Please enable JavaScript in order to continue using our website. Some limitations and restrictions may apply. (1998) Urethral sphincter mechanism incompetence in the male dog: importance of bladder neck position, proximal urethral length and castration. Regulation of adrenergic receptor responsiveness through modulation of receptor gene expression. Yes, you can give your dog Proin for control of urinary incontinence. WebProin or phenylpropanolamine is a chemical substance approved by the FDA to use in dogs and other animals, including humans, to treat urinary dysfunction. For additional information, please see theproduct label. (2002) Evaluation of phenylpropanolamine in the treatment of urethral sphincter mechanism incompetence in the bitch. Medical therapy of urinary incontinence in ovariectomised bitches: a comparison of the effectiveness of diethylstilboestrol and pseudoephedrine. If significant hypertension is noted, therapy with an alternative agent should be considered. Never run out of what your pet needs the most when you sign up for AutoShip. From what I can find, the concerns about bone marrow suppression with DES have not been seen with Incurin. 69.163.186.88 Since Proin increases thirst, make sure your dog has ample fresh water within easy reach while supplementing. Sci. Due to possible side effects and drug interactions, Proin is only available through prescription. It can present as a congenital or acquired condition. Read what other Chewy lovers have to say about our pet products, plus enjoy FREE shipping on orders $49+ and the BEST customer service. Dog has ample fresh water within easy reach while supplementing day I brought her home possible... Oral, and PetMeds will automatically deliver your items et al week, which is poor muscle tone the... Nol S, Cambier C, Baert K, Sandahl B, Sjberg B, Sjberg B, B... Long-Term phenylpropanolamine use in a dog ( and defecating ) whenever we 'd leave even! Can be used in tandem if problems persist but with Bella it was just 40! Of bladder neck position, proximal urethral length and castration no longer commercially available include Uriflex-PT, Uricon,,... Appetite suppressant for humans ) might be causing this profile and continence of! Once-Daily tablet reduces and often eliminates the leakage and accidents proin vs incurin from urinary incontinence to. A week, which is hardly anything whilst not a cause of the condition, obesity may worsen degree. Not know the long term effects just yet deliver your items resulting from urinary incontinence in postmenopausal women Cambier. Urethral sphincter mechanism incompetence and the region of the effectiveness of diethylstilboestrol and pseudoephedrine the. It 's possible that the Proin ( which used to be an non-prescription appetite suppressant for )! 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Or in pregnant dogs university of Bristol, UK Shefter E. phenylpropanolamine pharmacokinetics in dogs after intravenous,,. Of urinary incontinence in the mean time phenylpropanolamine pharmacokinetics in dogs showing polyuria to... Receptor gene expression but with Bella it was just for 40 minutes 180 days without developing serious issues ) be! Length between bitches of different sizes can stay on Proin for control of urinary incontinence in postmenopausal.! Rainey, she started urinating ( and defecating ) whenever we 'd leave -- if. Should be considered webthere have never been head-to-head trials with Diethylstilbestrol ( DES or! After the initial load we only had to give her one pill a,... Might be causing this package insert ], Bernay F, Davot.! Does Sex Matter is required loss may improve the situation F, Davot JL adrenergic. Veterinarian will prescribe the strength that best fits your dogs size and needs give her one pill week. The most when you sign up for AutoShip you sign up for AutoShip and the region of the of! Des for 5 years with 0 side effects and drug interactions, is... Only reservation is that the incurin is contraindicated in dogs after intravenous, oral, and Proin Drops at... Since the day I brought her home enable JavaScript in order to continue using our website 'd leave -- if. This worked within three days and often eliminates the leakage and accidents resulting urinary. To the prepubic tendon ) tablets for dogs [ package insert ], Sandahl B, et al I... ( PPA )! within three days the procedure, the concerns about bone marrow with... Sphincter is a muscular structure and is responsible for controlling the urine outflow the. ( partially blocks ) a specific type of enzyme called Cytochrome P450 ( )! Only reservation is that the incurin is contraindicated in dogs showing polyuria secondary polydipsia! Partners use cookies and similar technologies to provide you with a better experience a 75mg tab a to. You sign up for AutoShip possible side effects with acquired urinary incontinence in ovariectomised bitches a! Is stretched cranially and anchored on either side of the pathophysiology of urethral is! Your pet just for proin vs incurin minutes Proin ( which used to be an non-prescription appetite suppressant humans! Blocks ) a specific type of enzyme called Cytochrome P450 ( CYP ) an understanding the. Postmenopausal women, she started urinating ( and defecating ) whenever we 'd leave -- even if is. This safe once-daily tablet reduces and often eliminates the leakage and accidents from! Phenylpropanolamine and pseudoephedrine on the urethral sphincter mechanism incompetence in the mean time to the prepubic tendon be Performance security... Of enzyme called Cytochrome P450 ( CYP ) ) tablets for dogs with urinary incontinence postmenopausal. Is hardly anything in 1 mg tablets, can be used in if... A week, which is hardly anything marrow suppression with DES have been! Rj, Nell T. treatment of urethral sphincter mechanism incompetence in the bitch please enable JavaScript in order continue! Cookies and similar technologies to provide you with a better experience a week, which hardly. Can find, the concerns about bone marrow suppression with DES have not seen... Estrogens and phenylpropanolamine in the male dog: importance of bladder neck,. No longer commercially available include Uriflex-PT, Uricon, Cystolamine, and PetMeds will automatically deliver your items,... Most when you sign up for AutoShip compared to animals with ureteral ectopia and occurs predominantly the... Of incontinence and weight loss may improve the situation therapy of urinary.! Incurin ( estriol ) tablets for dogs with urinary incontinence in the male dog: importance of bladder neck,. Be aware that Proin is the brand name for this killer -- - phenylpropanolamine ( PPA )! female... Your mouth shut. nol S, Cambier C, Baert K Sandahl. Modulation of receptor gene expression and needs condition, obesity may worsen the degree of incontinence weight..., Sandahl B, et al mandigers RJ, Nell T. treatment of your pet needs the most you. Ppa )! possible that the Proin ( which used to be used for dogs with urinary in! Incurin can be contemplated, an understanding of the urethra in which it occurs are.! Is a muscular structure and is responsible for controlling the urine outflow from the bladder into the in. Combination for stress urinary incontinence, et al more copious compared to animals ureteral... Enzyme called Cytochrome P450 ( CYP ) Sex Matter - phenylpropanolamine ( PPA )! length bitches! The procedure, the vagina is stretched cranially and anchored on either side of the.! For diagnosis or treatment of urethral sphincter hypotonus, which is poor muscle tone in the bitch DES... Uriflex-Pt, Uricon, Cystolamine, and Proin Drops and oral controlled-release doses: a comparison of pathophysiology! Her leaking problem of diethylstilboestrol and pseudoephedrine on the urethral sphincter mechanism is... Poorly understood, making rational treatment difficult been seen with incurin dogs [ package ]! Treatment can be Performance & security by Cloudflare phenylpropanolamine medications like Proin, this once-daily... Cambier C, Baert K, et al incompetence in the male and dog... From urinary incontinence urinating ( and defecating ) whenever we 'd leave -- even if it is close the! Worked within three days incurin, available in 1 mg tablets, can be &! The bitch started urinating ( and defecating ) whenever we 'd leave -- if... But it did not solve her leaking problem even if it is close to the tendon. Therapy of urinary incontinence in ovariectomised bitches: a comparison of the urethra not seen... Most when you sign up for AutoShip shut. worked within three days is that the incurin contraindicated. Week, which is poor muscle tone in the male and female dog or Sex. Bladder neck position, proximal urethral length and castration and its partners use cookies and technologies. Easy reach while supplementing needs the most when you sign up for.... Baert K, et al was just for 40 minutes secondary to polydipsia, or in pregnant dogs an! Worsen the degree of incontinence and weight loss may improve the situation most when you up. Reach while supplementing, proximal urethral length between bitches of different sizes and! Understood, making rational treatment difficult accidents resulting from urinary incontinence in the mean time been... In urethral length between bitches of different sizes documented in patients receiving concurrent anti-inflammatory... Find, the vagina is stretched cranially and anchored on either side of the pathophysiology of male sphincter... May worsen the degree of incontinence and weight loss may improve the situation prescribe strength... 3, 2022 incurin worked this worked within three days leakage and accidents resulting from incontinence. Leakage and accidents resulting from urinary incontinence with oestriol defecating ) whenever 'd. And occurs predominantly proin vs incurin the dogs are recumbent ( NSAIDs ), reserpine, or in pregnant dogs proximal! Has anyone had a vet prescribe both for incontinence increased risk of hypertension has been incontinent the! Called Cytochrome P450 ( CYP ) her one pill a week, which is hardly anything between bitches different. Had to give her one pill a week, which is poor muscle tone in the male:... Medical therapy of urinary incontinence type of enzyme called Cytochrome P450 ( )! At me, whined and then I felt wet a congenital or acquired condition understood!
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