The https:// ensures that you are connecting to the 3 DOSAGE FORMS AND STRENGTHS Tablets: sitagliptin 50 mg and metformin HCl 500 mg tablets are light pink, capsule-shaped, film-coated tablets with 575 debossed on one side. In recent years, management of diabetes using symptom-based medicines against hyperglycemia or insulin resistance (such as metformin, sitagliptin and pioglitazone) and medicines for diabetes-related complications like adipose inflammation has drawn considerable attention. Fixed-dose combination medications - count each component as an individual medication. Sitagliptin plus metformin, as the fixed-dose tablet or a combination of the individual agents, was generally well tolerated in patients with type 2 diabetes, and was associated with a low risk of hypoglycaemia. and transmitted securely. Kidney damage, history ofMay increase risk for heart failure. Arechavaleta R, Seck T, Chen Y, Krobot KJ, O'Neill EA, Duran L, Kaufman KD, Williams-Herman D, Goldstein BJ. Study record managers: refer to the Data Element Definitions if submitting registration or results information. 2010 Jul;33(7):1509-15 Moreover, weekly injections of semaglutide for 72weeks reversed NASH and reduced ALT levels in NASH patients [145]. The patient's diabetes was being managed with insulin detemir 20units twice daily and sitagliptin-metformin (501000mg twice daily). For more information on generic medicines, see the question-and-answer document here. Independent peer-reviewed journal providing critical commentary on drugs and therapeutics for health professionals, Provides health professionals with timely, independent and evidence-based information, Our new and ongoing programs for healthcare professionals. Metformin reduces the absorption of sugar from the stomach, For this medicine, the following should be considered: Allergies Kaohsiung J Med Sci. government site. 2007 Sep;9(5):733-45. doi: 10.1111/j.1463-1326.2007.00744.x. This difference was not noted in the metformin+sitagliptin group. There was no significant difference noted in Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) after 16 weeks of triple treatment (1.202.80, P=0.092), but there was a significant increase noted in the metformin+sitagliptin group (1.662.33, P=0.024) [2C]. The hope is that adding SGLT1 inhibition would not only increase glucosuria from the kidney but also prevent glucose absorption from the diet triggering incretin responses, and this could substantially increase the potential weight loss. Clipboard, Search History, and several other advanced features are temporarily unavailable. Sitagliptin also reduces the amount of glucose made by the liver by increasing insulin levels and decreasing the levels of the hormone glucagon. A double-blind, placebo-controlled, randomized multicenter study that took place in Korea included 165 participants. Concerns have been raised, however, regarding potential adverse side effects as a result of prolonged inhibition of DPP-4 activity or off- target actions due to nonselectivity (105-108). Any additional effect a drug may have that reduces blood pressure (BP) would have a beneficial outcome to the patient. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. Delbar Daneshjou, Mohammad Ali Shariatzadeh, in Trends in Endocrinology & Metabolism, 2020. As for all medicines, data on the use of Sitagliptin/Metformin hydrochloride Accord are continuously monitored. This site complies with the HONcode standard for trustworthy health information: verify here. Metformin and Sitagliptin are often used in combination in the management of non-insulin dependent diabetes mellitus. 2016 Sep;42(4):290-1. doi: 10.1016/j.diabet.2016.03.005. Accessibility aerobic exercise, lipid lowering drugs, ACE inhibitors, calcium channel blockers, antidiabetic drugs including metformin, sitagliptin [8792]. This means that Sitagliptin/Metformin hydrochloride Accord contains the same active substances and works in the same way as a reference medicine already authorised in the EU called Janumet. -, Diabetes Obes Metab. Weakened physical conditionUse with caution. For more information on starting dual oral therapy with sitagliptin, see the NPS RADAR review on Dipeptidyl peptidase-4 inhibitors ('gliptins') for type 2 diabetes mellitus. Metformin works mainly by inhibiting glucose production and reducing its absorption in the gut. Sitagliptin/metformin is a single-tablet, fixed-dose combination of the dipeptidyl peptidase-4 inhibitor sitagliptin and the biguanide antihyperglycaemic metformin that achieves greater improvements in glycaemic control than either component alone in patients with type 2 diabetes mellitus. As a result, when metformin and sitagliptin are used together there is an additive effect on GLP-1 and GIP levels. Subsequently, the patient did not have any further episodes of pancreatitis over the next 9 months. 2005 Dec;78(6):675-88 From the results, it was observed that in patients receiving exenatide, 2-h PPG levels were significantly reduced compared to subjects receiving sitagliptin (133 vs 208mg/dL) Switching to sitagliptin from exenatide produced an increase of 73mg/dL in 2-h PPG level during the crossover period. WebAims: This study was conducted to compare the glycaemic efficacy and safety of initial combination therapy with the fixed-dose combination of sitagliptin and metformin versus metformin monotherapy in drug-naive patients with type 2 diabetes. Would you like email updates of new search results? However, a concern might be that if DPP-4 inhibition slows down glucagon secretion at low glucose levels as well, counter-regulation could be compromised. Similarly, two other case reports described the occurrence of empagliflozin-induced pancreatitis patients with Type 2 DM (Dziadkowiec et al., 2021 [A]; Zeidan et al., 2020 [A]). Alexander E. Berezin MD, PhDProfessor, Consultant of Therapeutic Unit, in Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 2017. Breastfeeding . Ann Emerg Med. The improved glycaemia with metformin is not associated with increased circulating levels of insulin, and the risk of hypoglycaemia with metformin is minimal. The therapeutic profile of metformin supports its use for the control of blood glucose, in diabetic patients and for the prevention of diabetes in subjects with impaired glucose tolerance. Drug information provided by: IBM Micromedex. Lactic acidosis, hypotension, and sensorineural hearing loss following intentional metformin overdose. Many studies conclude that metformin induces GLP-1 secretion and serum bile acid suppression and correlate well with changes in Bacteroidetes/Firmicutes ratio [39,40]. Thus, when sitagliptin was added to ongoing glimepiride, there was an increased incidence of hypoglycaemia (12% vs. 2% in the group given glimepiride alone).51 Furthermore, when vildagliptin was added to glimepiride, a slight increase in the incidence of hypoglycaemia was reported (1.2% vs. 0.6% during treatment with glimepiride alone)50; Therefore, a reduced dose of DPP-4 inhibitors or sulphonylureas is suggested when these are used in combination. It is indicated as triple combination therapy with a peroxisome proliferator-activated receptor gamma (PPAR) agonist (i.e., a thiazolidinedione) as an adjunct to diet and exercise in patients inadequately controlled on their maximal tolerated dose of metformin and a PPAR agonist. This helps lower the blood sugar level. An independent peer-reviewed journal providing critical commentary on drugs and therapeutics. Portions of this document last updated: Jan. 01, 2023. 14 When sitagliptin and metformin are administered in combination, the most Co-administration of 50 mg sitagliptin and 500 mg China-sourced metformin as individual tablets with 240 ml water on Day 1 of the relevant treatment period (Sit + Met500) after fasting for at least 10 hours. It is available in 25-, 50-, and 100-mg tablets. This is of advantage at high glucose levels. Overview. Changes since initial authorisation of medicine, Initial marketing-authorisation documents, Meeting highlights from the Committee for Medicinal Products for Human Use (CHMP) 16-19 May 2022, Send a question to the European Medicines Agency, International non-proprietary name (INN) or common name, Anatomical therapeutic chemical (ATC) code, Date of issue of marketing authorisation valid throughout the European Union. Publication No. -, Clin Pharmacol Ther. Though toxicity is rare, but occurs more frequently in This seemingly positive effect on BP must be managed carefully in poorly controlled elderly patients concurrently on hypertension medications where extensive BP reduction has the potential to lead to dizziness and syncope resulting in falls and potential bone fractures. View this study on Beta.ClinicalTrials.gov, U.S. Department of Health and Human Services, The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. GLP-1R agonist treatment reduces body weight and improves glucose homeostasis. NCI CPTC Antibody Characterization Program, N Engl J Med. J Drug Assess. A pooled analysis for sitagliptin in monotherapy showed that the incidence of hypoglycaemia was 1.2% after treatment with sitagliptin at 100mg daily versus 0.9% in the placebo group.1 Also as add-on therapy to metformin, DPP-4 inhibition shows a low degree of hypoglycaemia. Epub 2016 Apr 1. An official website of the United States government. A case study from a hospital in the United States discussed the occurrence of acute pancreatitis in a 51-year-old Hispanic male after taking dapagliflozin, a SGLT2 inhibitor (Sujanani et al., 2020) [A]. 2010 May;12(5):442-51 Mechanism of action For non-prescription products, read the label or package ingredients carefully. sitagliptin Sitagliptin: a review of its use in the management of type 2 diabetes mellitus. Our COVID-19 information hub has important information for everyone, including resources about vaccines and treatments. The Trial Evaluating Cardiovascular Outcomes with Sitagliptin P = 0.001), but so too was a trend toward a statistically significant increased risk with other combinations: metformin and thiazolidinedione (HR 1.024; 95% CI, 0.98-1.07) and metformin and a GLP-1 receptor agonist (HR 1.1; 95% CI, 0.99-1.22). However, the cost of By continuing you agree to the use of cookies. Type 2 diabetes is a disease in which the pancreas does not make enough insulin to control the level of glucose in the blood or where the body is unable to use insulin effectively. Would you like email updates of new search results? Some studies have reported very interesting facts about metformin, such as its capacity to induce mucin expression similar to Akkermansia muciniphila [40]. Half-life of saxagliptin is 12.4h (Merck and Co, 2010). For more information about using Sitagliptin/Metformin hydrochloride Accord, see the package leaflet or contact your doctor or pharmacist. Sitagliptin, however, increases both GLP-1 and GIP concentrations. Keep track of medicines and access important health info any time and anywhere, especially in emergencies. A fixed-dose combination of sitagliptin and metformin is indicated to improve glycemic control in adults with type II diabetes mellitus when treatment with both sitagliptin and metformin is appropriate. Sitagliptin And Metformin (Oral Route) Before Using Drug information provided by: IBM Micromedex In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. Find information on medicines by active ingredient or brand name. Web Fixed-dose combination medications - count each component as an individual medication. For general information, Learn About Clinical Studies. people are stabilised on a PBS-subsidised regimen of oral medicines for diabetes that includes metformin and sitaglitpin. EPCs are involved in the homeostasis of the heart and vessels, and their exhaustion or dysfunction may accelerate the course of DM-related CV complications. The new combination is the second such product joining Kombiglyze XR, which combines saxagliptin and eCollection 2016. Because Sitagliptin/Metformin hydrochloride Accord is a generic medicine and is bioequivalent to the reference medicine, its benefits and risks are taken as being the same as the reference medicines. Mayo Clinic on Incontinence - Mayo Clinic Press, NEW The Essential Diabetes Book - Mayo Clinic Press, NEW Mayo Clinic on Hearing and Balance - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press. A sitagliptin/metformin combination was approved by the FDA in Apr. Metformin and Sitagliptin are often used in combination in the management of non-insulin dependent diabetes mellitus. Your doctor may gradually increase your dose until your blood sugar is As part of triple combination therapy, also in treatment-experienced patients with inadequate glycaemic control, sitagliptin added to ongoing glimepiride with or without metformin or ongoing insulin with or without metformin significantly improved glycaemic control over 24 weeks. We use cookies to help provide and enhance our service and tailor content and ads. Whereas this is insufficient BW reduction as a registrable endpoint for an obesity indication, it certainly plays a part in risk reduction from a cardiovascular and diabetic standpoint. Finally, cotadutide, a dual GLP-1R/glucagon receptor agonist, which mimics the effects of oxyntomodulin, an intestinal peptide dual glucagon receptor and GLP-1R activator, reduced body weight and improved liver histology in mice [146]. Dapagliflozin, saxagliptin, and metformin combination is used with proper diet and exercise to lower high blood sugar levels caused by type 2 diabetes. Chow, in International Review of Cell and Molecular Biology, 2016. Margaux Nawrot, Bart Staels, in Metabolism, 2021. Therefore, based on the aforementioned evidence, we suggest that the use of sitaformin may be more effective than individual metformin or sitagliptin treatments in reducing insulin resistance and improving the metabolic profile, ovulation, and comorbid conditions in patients with PCOS. Co-administration of 50 mg sitagliptin and 850 mg China sourced metformin as individual tablets with 240 ml water on Day 1 of the relevant treatment period (Sit + Met850) after fasting for at least 10 hours. Metformin and sitagliptin may also be used for purposes not listed in this medication guide. Physical examination revealed tenderness to light palpation diffusely in his abdomen with no guarding or rebound tenderness. Journal of the Association of Physicians of India 2011. Thus, when compared to sulphonylurea as add-on to metformin, sitagliptin showed substantially lower risk of hypoglycaemia (5%) than glipizide (32%).46 When combined with sulphonylurea, GLP-1 receptor agonists show increased risk of hypoglycaemia.10 This has been observed also for DPP-4 inhibition. Results provided evidence that compared to sitagliptin, both doses of liraglituide exhibited superior effectiveness in glycemic control (0.9, 1.5, and 1.24%, respectively). European Medicines AgencyDomenico Scarlattilaan61083 HS AmsterdamThe Netherlands. This helps lower the blood sugar level. -, Lancet. It has been used as a monotherapy or in combination with other diabetic agents such as metformin, sulfonylureas, and pioglitazone. Sitagliptin is a dipeptidyl-peptidase-4 (DPP-4) inhibitor. However, since diabetes is known as a lifestyle disorder, for better results, the drugs must be taken along with a healthy diet and a sufficient amount of exercise. Giampietro O, Giampietro C, Bartola LD, Masoni MC, Matteucci E. Drug Des Devel Ther. Methods: This double-blind study (18-week Phase A and 26-week Phase B) randomized 1250 drug This site needs JavaScript to work properly. 2007 and is available under the trade name Janumet (Merck) in doses of 50/500mg or 50/1000mg. Janumet XR is a new formulation of the sitagliptin/metformin combination that is taken once daily with the evening meal. Both Akkermansia and metformin administration to mice fed on high-fat diet are associated with a decrease in IL-1 and IL-6 expression in adipose tissue. Janumet XR combines sitagliptin and metformin. As compared with insulin injection, early treatment with sitagliptin combined with metformin in newly diagnosed patients with T2DM and severe hyperglycaemia produced non-inferior outcomes with regards to glycaemic remission. A diagnosis of pancreatitis was made. Dapagliflozin and sitagliptin were discontinued. Epub 2013 Feb 14. The very small number of adverse side effects in subjects with sitagliptin treatment provides evidence for their potential space in clinical usage. Magnetic resonance imaging revealed a macroadenoma. A 2020 Cochrane systematic review did not find enough evidence of reduction of all-cause mortality, serious adverse events, cardiovascular mortality, non-fatal myocardial infarction, non-fatal stroke or end-stage renal disease when comparing metformin monotherapy to meglitinide for the treatment of type 2 diabetes. FOIA WebUsed together, sitagliptin (Januvia) and metformin (Glucophage) help to improve glycemic levels in diabetic patients, suggesting a synergy between the agents. As add-on therapy in treatment-experienced patients with inadequate glycaemic control, the HbA(1c)-lowering efficacy of sitagliptin plus metformin was noninferior to that of glimepiride plus metformin in a 30-week, double-blind trial. Bo Ahrn MD, PhDProfessor, in Best Practice & Research Clinical Endocrinology & Metabolism, 2009. Improving clinical practice and health outcomes for Australia. Unable to load your collection due to an error, Unable to load your delegates due to an error. Careers. Yamada T, Shojima N, Yamauchi T, Kadowaki T. Diabetes Metab. Take the extended-release tablets as directed in the evening. doi: 10.1097/MD.0000000000008161. The presence of other medical problems may affect the use of this medicine. Talk with your doctor and family members or friends about deciding to join a study. Angioedema (swelling of the face, lips, tongue, throat, arms, or legs), history with this medication or other dipeptidyl peptidase-4 (DPP-4) inhibitorsUse with caution. Sitagliptin and Metformin provide great results for diabetic patients and are the best combinational anti-diabetic drugs available in the market. Subjects taking 1500mg or greater metformin at screening will enter a 6 week stable dose period followed by a 54 week treatment period. For patients who are less flexible to changes in their current metformin regimen for example, because of tolerability it may be preferable to start or continue with sitagliptin and metformin as separate medicines. The reported numbers of hypoglycaemic events in studies with vildagliptin and sitagliptin are very low. An official website of the United States government. Timely, independent, evidence-based information on new drugs and medical tests, and changes to the PBS and MBS. However, the cost of sitagliptin and the need for more data may restrict its use. This medicines product information is available in all official EU languages.Select available languages to access the language you need. You can findproduct informationdocuments for centrally authorised human medicines on this website. Advertising revenue supports our not-for-profit mission. Pharmacologic Class: Sitagliptin Chemical Class: Metformin Uses for sitagliptin and metformin Metformin and sitagliptin combination is used to treat high blood sugar levels caused by type 2 diabetes. Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. Uses Before taking Warnings Side effects Overdose Dosage Warning Rarely, metformin may cause an acid health problem (lactic GI side-effects were more frequent in patients treated with metformin, both in monotherapy (11.6% versus 2.5% with gliclazide MR and 4% with rosiglitazone) and in combination therapy (12.3% with metformin and gliclazide MR, 10% with metformin plus rosiglitazone, and 3.3% with gliclazide MR and rosiglitazone). Metformin reduces the absorption of sugar from the stomach, reduces the release of stored sugar from the liver, and helps your body use sugar better. Since the renal and hepatic pathways are involved in the elimination of oral doses of sitagliptin, it has also been tested in patients with renal and hepatic insufficiency. (e.g., Avandamet [rosiglitazone + metformin] is considered 2-drug components); Up to 3 medications total are considered acceptable for routine treatment according to generally accepted standards of care for diabetes (American WebIn this study, we compare two strategies: initial combination therapy with sitagliptin/metformin as a fixed-dose combination (FDC) and initial metformin monotherapy, with the option to add additional antihyperglycaemic agents (AHAs) in either treatment arm during the second phase of the study in order to reach adequate glycaemic This is a decision you and your doctor will make. Carefully follow the special meal plan your doctor gave you. Sitagliptin/metformin fixed-dose combination in type 2 diabetes mellitus: an evidence-based review of its place in therapy. sitagliptin 50 mg and metformin HCl 1000 mg 4 CONTRAINDICATIONS Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Complementary to physical exercise and dietary intervention, activation of the GLP-1R either by subcutaneous injection of semi-synthetic recombinant GLP-1R agonists or per os treatment with a gliptin, which inhibits the GLP-1-degrading dipeptidyl peptidase-4 (DPP-4) hence increasing endogenous active GLP-1 concentrations, are largely used therapeutic options for the treatment of obesity and T2D. By now, the results of the recently performed investigations have shown that EPCs dysfunction in DM remains to be unresolved yet. The authority-required listing for sitagliptin (Januvia) has been revised and is now streamlined to be consistent with the listing for Janumet.1, Sitagliptin with metformin fixed-dose combination tablets should be taken twice daily with meals.2 If necessary, increase the dose gradually so as to minimise gastrointestinal side effects with metformin.2, Individualise the starting or switching dose according to the patient's current regimen, level of glycaemic control and tolerability, while maintaining a daily dose of sitagliptin of 100 mg/day.2, The initial dose for patients who are inadequately controlled on metformin is sitagliptin 50 mg twice daily plus the previous dose of metformin.2, For patients who are already taking sitagliptin and metformin, a fixed-dose combination tablet may be prescribed at the dose of each medicine that was used separately.2. This medicine is available only with your doctor's prescription. May increase the risk of this condition occurring again. 1993 Sep 30;329(14):977-86 The European Medicines Agency concluded that, in accordance with EU requirements, Sitagliptin/Metformin hydrochloride Accord has been shown to have comparable quality and to be bioequivalent to Janumet. 2009/0105265 discloses compositions comprising sitagliptin and metformin. The .gov means its official. Mayo Clinic does not endorse companies or products. 2010 Mar 5;70(4):489-512. doi: 10.2165/11203790-000000000-00000. The patient was not allowed any food by mouth and was managed with intravenous fluids, antiemetics, and insulin. It works by blocking the breakdown of incretin hormones in the body. 20 years of helping Australians make better decisions about medicines, medical tests and other health technologies. -. The .gov means its official. Epub 2009 Jun 25. This medicine does not help patients who have insulin-dependent or type 1 diabetes. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. As for every medicine, the company provided data on the quality of Sitagliptin/Metformin hydrochloride Accord. Drugs R D. 2022 Mar;22(1):15-23. doi: 10.1007/s40268-021-00371-2. In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. Careers. Diabetic ketoacidosis or metabolic acidosis (high ketones and acid in the blood) or. Another interesting observation is that in the study in which vildagliptin was added to insulin, the number of hypoglycaemic events was lower in the vildagliptin-treated group (113 events) than in the placebo-treated group (185 events) in association with the more efficient reduction in HbA1c.52 Overall, these studies show a low risk for hypoglycaemia during treatment with DPP-4 inhibition. Dapagliflozin was subsequently discontinued and the patient's symptoms were resolved. Before All these findings elucidate that EPCs dysfunction could be an alternative therapeutic target to promoting heart and vessels repair in patients with DM. Epub 2007 Jun 26. Although it is unclear at present whether fibrosis improves upon GLP-1R agonist treatment, this compound is of high interest given the fact that it can also be administered orally. WebThe most common adverse effects associated with sitagliptin include upper respiratory infections, nasopharyngitis, and headaches. Clipboard, Search History, and several other advanced features are temporarily unavailable. Seven days after the initiation of dapagliflozin, the patient again presented to the emergency room with symptoms of pancreatitis. manufacturing authorisationholder responsible for batch release (annex IIA); It is indicated as an adjunct to diet and exercise to improve glycaemic control in patients inadequately controlled on their maximal tolerated dose of metformin alone or those already being treated with the combination of sitagliptin and metformin. AUC (0-t) is the area under the curve for the plot showing plasma concentration against time from time zero to the time of the last quantifiable concentration for sitagliptin 50 mg, metformin 500 mg and metformin 850 mg. Cmax is the peak serum concentration of a therapeutic drug after administration; and is used to determine the rate and extent of drug absorption. Relevant, timely and evidence-based information for Australian health professionals and consumers. SitMet500 FDC / Sit + Met850 / Sit + Met500 / SitMet850 FDC, Experimental: 3. Sitagliptin with metformin fixed-dose combination tablets provide metformin at a total daily dose of 1000 mg, 1700 mg or 2000 mg. Diabetes more effectively treated with immediate sitagliptin, metformin combination therapy. May increase risk for pancreatitis (swelling of the pancreas). Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. Laura A. Schalliol PharmD, BCACP, Sidhartha D. Ray PhD, FACN, in Side Effects of Drugs Annual, 2019. Episode 51: Quit smoking. Successful treatment of severe lactic acidosis caused by a suicide attempt with a metformin overdose. Overview. The patient was discharged and placed on the following medications: insulin and metformin. Miller DK, Brinson AJ, Catalano G, Catalano MC. Together, these processes reduce blood glucose levels and help to control type 2 diabetes. However, an ability of BM-EPCs and PB-EPCs to restore of structure and function of cardiac and vessels in DM is sufficiently impaired [86]. Do not crush, break, or chew it. PMC Shi P, Liu X, Li T, Sun FF, Liu YP, Liu SQ, Gao XM, Ma YP, Fu Y, Cao Y. Unfortunately, the only dual SGLT1/2 inhibitor, LX4211, does not appear to differentiate from the SGLT2-selective agents and produces a similar 23% reduction in BW. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. Scheen AJ, Charpentier G, Ostgren CJ, Hellqvist A, Gause-Nilsson I. Diabetes Metab Res Rev. However, 1.8mg (27%) and 1.2mg (21%) liraglutide treatment group had higher incidence of nausea than 100mg sitagliptin (5%). Any queries concerning reproduction and rights should be sent to [emailprotected]We acknowledge the provision of funding from the Australian Government Department of Health and Aged Care to develop and maintain this website.
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